Genomic Affinities of Two 7,000-Year-Old Iberian Hunter-Gath

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PostPosted: Thu Jun 28, 2012 9:49 pm
Federico Sánchez-Quinto, Hannes Schroeder, Oscar Ramirez, María C. Ávila-Arcos, Marc Pybus, Iñigo Olalde, Amhed M.V. Velazquez, María Encina Prada Marcos, Julio Manuel Vidal Encinas, Jaume Bertranpetit, Ludovic Orlando, M. Thomas P. Gilbert, and Carles Lalueza-Fox, Genomic affinities of two 7,000-year-old Iberian hunter-gatherers, Current Biology, Available online 28 June 2012


The genetic background of the European Mesolithic and the extent of population replacement during the Neolithic is poorly understood, both due to the scarcity of human remains from that period and the inherent methodological difficulties of ancient DNA research. However, advances in sequencing technologies are both increasing data yields and providing supporting evidence for data authenticity, such as nucleotide misincorporation pattern. We use these methods to characterize both the mitochondrial DNA genome and generate shotgun genomic data from two exceptionally well-preserved 7,000-year-old Mesolithic individuals from La Brana-Arintero site in Leon (Northwestern Spain) . The mitochondria of both individuals are assigned to U5b2c1, a haplotype common among the small number of other previously studied Mesolithic individuals from Northern and Central Europe. This suggests a remarkable genetic uniformity and little phylogeographic structure over a large geographic area of the pre-Neolithic populations. Using Approximate Bayesian Computation, a model of genetic continuity from Mesolithic to Neolithic populations is poorly supported. Furthermore, analyses of 1.34% and 0.53% of their nuclear genomes, containing about 50,000 and 20,000 ancestry informative SNPs, respectively, show that these two Mesolithic individuals are not related to current populations from either the Iberian Peninsula or Southern Europe.

Commentary and images from Dienekes: Mesolithic Iberians (La Braña-Arintero) not ancestors of modern ones
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PostPosted: Fri Jun 29, 2012 12:44 am
Very interesting, I hope thay can publish the Y DNA.
Y DNA - Barcelos - Minho - Portugal. Colonial Brazil
MtDNA - Ilha Terceira, Azores, Portugal
Brazilian Portuguese Founding People

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PostPosted: Fri Jun 29, 2012 9:41 am
They are intending to publish further.
According to Lalueza-Fox, this is only a first result since the intention of the team is to recover the complete DNA of these individuals, and to compare it with that of the modern humans. CSIC researcher discloses: "The arrival of the Neolithic Period brought about a replacement of populations, and could cause genetic changes in genes associated with new infectious diseases, and in metabolic genes linked to changes in diet. Therefore, all the information extracted from this genome will be absolutely important". ... 062512.php

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